CUBE

Dr. Adrian James Tett

Junior Group Leader at the Division of Computational Systems Biology
 

☎ +43 1 4277 91290
✉ adrian.james.tett(at)univie.ac.at


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Adrian Tett’s group develops and utilises computational approaches combined with metagenomics to understand the human microbiome in fine detail. Specifically, the group explores the hidden diversity in novel species and subspecies and its relationship to health or disease. Adrian’s group exploits the thousands of available metagenomes and uses large-scale metanalyses to identify and target potentially important microbiome members for further analysis and characterisation. For instance, the group was involved in revealing the gut bacterium Prevotella copri to be far more diverse than appreciated, which, with further ongoing characterisation, may explain the conflicting reports of P. copri in human health. Another focus is utilising ancient microbial fossils and pre-industrialised populations to determine how industrialisation has dramatically and rapidly changed the co-evolved human microbiome and the potential implications on human health.

Group Members

Gillian Gandalf

Publications

Yu XA, Strachan CR, Herbold CW, Lang M, Gasche C, Makristathis A et al. Genome-wide sweeps create ecological units in the human gut microbiome. Nature. 2026 Jul 2;655(8121):202-209. doi: 10.1038/s41586-026-10476-w

Blanco-Míguez A, Beghini F, Cumbo F, McIver LJ, Thompson KN, Zolfo M et al. Extending and improving metagenomic taxonomic profiling with uncharacterized species using MetaPhlAn 4. Nature Biotechnology. 2023 Nov;41(11):1633-1644. Epub 2023 Feb 23. doi: 10.1038/s41587-023-01688-w

Valles-Colomer M, Blanco-Míguez A, Manghi P, Asnicar F, Dubois L, Golzato D et al. The person-to-person transmission landscape of the gut and oral microbiomes. Nature. 2023 Feb 2;614(7946):125-135. doi: 10.1038/s41586-022-05620-1

Sarhan MS, Lehmkuhl A, Straub R, Tett AJ, Wieland G, Franken M et al. Ancient DNA diffuses from human bones to cave stones. iScience. 2021 Dec 17;24(12):103397. 103397. Epub 2021 Nov 23. doi: 10.1016/j.isci.2021.103397

Maixner F, Sarhan MS, Huang KD, Tett A, Schoenafinger A, Zingale S et al. Hallstatt miners consumed blue cheese and beer during the Iron Age and retained a non-Westernized gut microbiome until the Baroque period. Current Biology. 2021 Dec 6;31(23):5149-5162. Epub 2021 Oct 13. doi: 10.1016/j.cub.2021.09.031

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