Univ. Prof. Dr. Thomas Rattei






Head of the Division of Computational Systems Biology
Vice-head of the Department of Microbiology and Ecosystem Science

☎ +43 1 4277 91280


Thomas Rattei’s work covers a wide spectrum of topics from bioinformatics, genome and metagenome analysis and systems biology. He has long-standing expertise in developing and applying computational methods for the interpretation of large-scale sequence information. The international reputation of his research group triggered their involvement in numerous international (meta-) genome sequencing and analysis consortia.

Thomas’ research activities not only cover individual, project-specific questions but also general problems in bioinformatics, computational infrastructure, and large-scale biological databases. Furthermore, his group develops novel, genome-based computational approaches for studying molecular inter-species interactions, such as between hosts and pathogens, between symbionts, or in microbial ecosystems.

Thomas and his team maintain and develop internationally relevant resources in computational biology, such as the web portals phendb.org, vogdb.org and effectivedb.org for microbial trait prediction, virus orthologous groups and protein families, and bacterial secreted proteins and secretion systems.



To explore Thomas' teaching activities at the University of Vienna, visit u:find.

Join the Team

If you are interested in joining the lab, explore open positions here or email Thomas directly.

Group Members

  • Michael Neumayer
  • Alexander Pfundner
  • Michael Predl
  • Roko Sango
  • Lovro Trgovec-Greif


Sudo M, Osvatic J, Taylor JD, Dufour SC, Prathep A, Wilkins LGE et al. SoxY gene family expansion underpins adaptation to diverse hosts and environments in symbiotic sulfide oxidizers. mSystems. 2024 Jun;9(6):e01135-23. Epub 2024 May 15. doi: 10.1128/msystems.01135-23

Esser SP, Rahlff J, Zhao W, Predl M, Plewka J, Sures K et al. A predicted CRISPR-mediated symbiosis between uncultivated archaea. Nature Microbiology. 2023 Sep 1;8(9):1619-1633. Epub 2023 Sep. doi: 10.1038/s41564-023-01439-2

Collingro A, Köstlbacher S, Siegl A, Toenshoff ER, Schulz F, Mitchell SO et al. The Fish Pathogen "Candidatus Clavichlamydia salmonicola"-A Missing Link in the Evolution of Chlamydial Pathogens of Humans. Genome Biology and Evolution. 2023 Aug 24;15(8):evad147. doi: 10.1093/gbe/evad147

Herrera P, Schuster L, Zojer M, Na H, Schwarz J, Wascher F et al. Genome Dynamics and Temperature Adaptation During Experimental Evolution of Obligate Intracellular Bacteria. Genome Biology and Evolution. 2023 Jul 29;15(8):evad139. doi: 10.1093/gbe/evad139

Olmo R, Wetzels SU, Berg G, Cocolin L, Hartmann M, Hugas M et al. Food systems microbiome-related educational needs. Microbial Biotechnology. 2023 Jul;16(7):1412-1422. doi: 10.1111/1751-7915.14263

Graffius S, Garzón JFG, Zehl M, Pjevac P, Kirkegaard R, Flieder M et al. Secondary Metabolite Production Potential in a Microbiome of the Freshwater Sponge Spongilla lacustris. Microbiology Spectrum. 2023 Apr 13;11(2):e04353-22. Epub 2023 Feb 2. doi: 10.1128/spectrum.04353-22, 10.1128/spectrum.04353-22

Tveit AT, Söllinger A, Rainer EM, Didriksen A, Hestnes AG, Motleleng L et al. Thermal acclimation of methanotrophs from the genus Methylobacter. The ISME Journal. 2023 Apr 1;17(4):502-513. Epub 2023 Jan 18. doi: 10.1038/s41396-023-01363-7

Viljakainen L, Fürst MA, Grasse AV, Jurvansuu J, Oh J, Tolonen L et al. Antiviral immune response reveals host-specific virus infections in natural ant populations. Frontiers in Microbiology. 2023 Mar 16;14:1119002. doi: 10.3389/fmicb.2023.1119002

Lüftinger L, Májek P, Rattei T, Beisken S. Metagenomic Antimicrobial Susceptibility Testing from Simulated Native Patient Samples. Antibiotics. 2023 Feb 9;12(2):366. doi: 10.3390/antibiotics12020366

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